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R0002/2026-03-13/C010 — ACH Matrix

Matrix

H1: No combination exists H2: Partial combinations exist H3: Similar combination exists
SRC01-E01: JMIR clinical domain only + N/A N/A
SRC02-E01: Frontiers medical domain only + N/A N/A
S01 null result: IC + scientific search + N/A N/A
S02 null result: ICD 203 + CONSORT/ROBIS + N/A N/A
S03 null result: LLM + analytic techniques + N/A N/A
S04 null result: AI prompt cross-domain + N/A N/A

Legend: - ++ Strongly supports - + Supports - -- Strongly contradicts - - Contradicts - N/A Not applicable to this hypothesis

Diagnosticity Analysis

Most Diagnostic Evidence

Evidence ID Why Diagnostic
S02 null result The most targeted search (ICD 203 + CONSORT + ROBIS + prompt) returned only IC-domain results. If a cross-domain combination existed, this search was most likely to find it. Its null result is the most diagnostic evidence supporting H1.

Least Diagnostic Evidence

Evidence ID Why Non-Diagnostic
SRC01-E01, SRC02-E01 These sources document domain-specific work. Their absence of cross-domain content is expected and does not strongly discriminate between hypotheses -- individual papers are not expected to survey all possible combinations.

Outcome

Hypothesis supported: H1 -- No evidence found of a prior systematic combination. Four independent search strategies converged on the same null result. However, this is supported by absence of evidence, not positive confirmation.

Hypotheses eliminated: None -- universal negatives cannot be conclusively proven. H2 and H3 are not supported but cannot be definitively eliminated.

Hypotheses inconclusive: H2 and H3 -- Not supported by any evidence found, but the search was limited to web-accessible sources. Both remain theoretically possible.

Special Note: Conflict of Interest

The researcher is the author of the hybrid prompt and has a direct interest in the novelty claim. This is the highest-risk claim for confirmation bias. The null result should be interpreted cautiously, and the claim should use hedged language ("to our knowledge") rather than an absolute negative.