R0002/2026-03-13/C005/SRC02¶
Nejadghaderi et al. 2024
Source¶
Nejadghaderi SA, et al. "Comparison of Risk of Bias 2 and Original Risk of Bias." PMC11147813. 2024.
URL: Not captured — experimental run
Summary¶
| Dimension | Rating |
|---|---|
| Reliability | High |
| Relevance | High |
| Bias: Missing data | Low risk |
| Bias: Measurement | Low risk |
| Bias: Selective reporting | Low risk |
| Bias: Randomization | N/A — not an RCT |
| Bias: Protocol deviation | N/A — not an RCT |
| Bias: COI/Funding | Some concerns — authors advocate for including funding/COI |
Rationale¶
| Dimension | Rationale |
|---|---|
| Reliability | Peer-reviewed comparison study published in a PubMed Central indexed journal. Systematic approach comparing two versions of the RoB tool. Quantitative data on domain usage. |
| Relevance | Directly addresses the comparison between RoB 2 and the original RoB, including the removal of the "other bias" domain. Provides the key data point that funding (15.6%) and COI (5.8%) were frequently assessed in RoB 1's "other bias" domain. |
| Bias flags | Authors advocate for expanding RoB domains to include funding/COI. This perspective is favorable to the claim's "conspicuously absent" framing. Noted as a potential source of bias but mitigated by the inclusion of Sterne's counterargument (SRC03). |
Evidence Extracts¶
| Evidence ID | Summary |
|---|---|
| SRC02-E01 | "Other bias" domain removed in RoB 2; funding assessed 15.6% of time in RoB 1 |
| SRC02-E02 | Recommends funding source be considered in future revisions |