SRC02¶


Research	R0002 — Research Standards for AI-Assisted Writing
Run	2026-03-13
Claim	C002
Search	S01, S02, S04
Result	S01-R04, S02-R01, S04-R01
Source	SRC02

CDC ACIP GRADE Handbook

Source¶

Centers for Disease Control and Prevention. "GRADE Evidence to Recommendations Framework." CDC ACIP Handbook. https://www.cdc.gov/. Accessed 2026-03-13.

URL: Not captured — experimental run

Summary¶

Dimension	Rating
Reliability	High
Relevance	High
Bias: Missing data	Low risk
Bias: Measurement	N/A — implementation guidance
Bias: Selective reporting	Low risk
Bias: Randomization	N/A — not an RCT
Bias: Protocol deviation	N/A — not an RCT
Bias: COI/Funding	Low risk

Rationale¶

Dimension	Rationale
Reliability	US government health agency guidance. The CDC's Advisory Committee on Immunization Practices (ACIP) is a major institutional adopter of GRADE. Government publication with editorial oversight.
Relevance	Operational implementation of GRADE with specific criteria names. Provides independent institutional confirmation of the framework structure. Exact topic match.
Bias flags	Institutional adoption may simplify nuances from the original GRADE framework. However, the structural elements (counts, criteria names) are faithfully reproduced.

Evidence Extracts¶

Evidence ID	Summary
SRC02-E01	Three upgrade criteria confirmed
SRC02-E02	All structural elements independently confirmed