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R0002/2026-03-13/C002/SRC01

Guyatt et al. 2008 BMJ

Source

Guyatt GH, Oxman AD, Vist GE, et al.; GRADE Working Group. "GRADE: an emerging consensus on rating quality of evidence and strength of recommendations." BMJ. 2008;336(7650):924-926. PMC2335261.

URL: Not captured — experimental run

Summary

Dimension Rating
Reliability High
Relevance High
Bias: Missing data Low risk
Bias: Measurement N/A — framework definition
Bias: Selective reporting Low risk
Bias: Randomization N/A — not an RCT
Bias: Protocol deviation N/A — not an RCT
Bias: COI/Funding Noted — authors are GRADE developers

Rationale

Dimension Rationale
Reliability Foundational GRADE publication by the working group. Published in BMJ, peer-reviewed, highly cited. This is THE definitional source for GRADE.
Relevance Directly defines the framework that the claim references. Primary source — this IS the GRADE framework definition. Exact topic match.
Bias flags COI/Funding — Noted: Authors are GRADE developers. However, this is the definitional source — COI is inherent and expected for a framework's own publication. No alternative authoritative source exists for the definition.

Evidence Extracts

Evidence ID Summary
SRC01-E01 GRADE explicitly separates evidence quality from recommendation strength
SRC01-E02 Four certainty levels: High, Moderate, Low, Very low
SRC01-E03 Five downgrade criteria confirmed