R0002/2026-03-13/C002/SRC01¶
Guyatt et al. 2008 BMJ
Source¶
Guyatt GH, Oxman AD, Vist GE, et al.; GRADE Working Group. "GRADE: an emerging consensus on rating quality of evidence and strength of recommendations." BMJ. 2008;336(7650):924-926. PMC2335261.
URL: Not captured — experimental run
Summary¶
| Dimension | Rating |
|---|---|
| Reliability | High |
| Relevance | High |
| Bias: Missing data | Low risk |
| Bias: Measurement | N/A — framework definition |
| Bias: Selective reporting | Low risk |
| Bias: Randomization | N/A — not an RCT |
| Bias: Protocol deviation | N/A — not an RCT |
| Bias: COI/Funding | Noted — authors are GRADE developers |
Rationale¶
| Dimension | Rationale |
|---|---|
| Reliability | Foundational GRADE publication by the working group. Published in BMJ, peer-reviewed, highly cited. This is THE definitional source for GRADE. |
| Relevance | Directly defines the framework that the claim references. Primary source — this IS the GRADE framework definition. Exact topic match. |
| Bias flags | COI/Funding — Noted: Authors are GRADE developers. However, this is the definitional source — COI is inherent and expected for a framework's own publication. No alternative authoritative source exists for the definition. |
Evidence Extracts¶
| Evidence ID | Summary |
|---|---|
| SRC01-E01 | GRADE explicitly separates evidence quality from recommendation strength |
| SRC01-E02 | Four certainty levels: High, Moderate, Low, Very low |
| SRC01-E03 | Five downgrade criteria confirmed |