R0002/2026-03-13/C002/SRC01/E03¶
Five Downgrade Criteria Confirmed
URL: Not captured — experimental run
Extract¶
GRADE defines five criteria for downgrading the certainty of evidence:
- Risk of bias (limitations in study design or execution)
- Inconsistency (unexplained heterogeneity of results)
- Indirectness (indirect population, intervention, control, or outcomes)
- Imprecision (wide confidence intervals)
- Publication bias (selective publication of studies)
These five criteria are confirmed by both the seminal GRADE paper and the CDC implementation handbook.
Relevance to Hypotheses¶
| Hypothesis | Relationship | Strength |
|---|---|---|
| H1 | Supports | Strong — confirms five downgrade criteria |
| H2 | Supports | Strong — structural detail is correct |
| H3 | Contradicts | Strong — five criteria is confirmed, not wrong |
Context¶
The five downgrade criteria have remained stable since the framework's introduction. They are consistently listed across all GRADE implementations and training materials. No source disputes the count or the criteria names.
Notes¶
None.